Prof. Brunetti
ARTURO BRUNETTI, M.D.
Personal data:
born in 1958;
Istituto di Biostrutture e Bioimmagini CNR
c/o Diagnostic Imaging Department
Università degli Studi di Napoli "Federico II"
Via Pansini 5, Naples I-80131 - Italy
Tel +39-081-7463102 081-2203187 (ext 417)
FAX +39-081-2296117
E-mail: brunetti@.unina.it or arturo.brunetti@ibb.cnr.it

EDUCATION
  • 1982 Laurea in Medicina e Chirurgia (M.D. Degree) Naples University, 1st Medical School -
  • 1985 Board Certification in Nuclear Medicine Catholic University "Gemelli" - Medical School - Rome
  • 1989 Board Certification in Diagnostic Radiology Napoli University "Federico II" Medical School


    • CURRENT POSITION
  • Full Professor, Diagnostic Imaging Medical School, Università degli Studi di Napoli "Federico II" and Chief - Neuroradiology Unit University Hospital - Università degli Studi di Napoli "Federico II" since 2005
  • Supervisor Laboratory of the Centre of eccellence for the study of genetic diseases of man and of their animal models Università degli Studi di Napoli "Federico II" c/o CEINGE Biotecnologie Avanzate since 2003
  • Representative of CNR (Consiglio Nazionale delle Ricerche) in the Standing Committee of the European Medical Research Council - European Science Foundation since 2003


    • CURRENT RESEARCH INTERESTS
  • Functional characterization of degenerative and neoplastic disorders of the Central Nervous System
  • Post-processing and "fusion" of morphologic and functional imaging studies.
  • Quantitative assessment of brain damage and clinical correlates in multiple sclerosis
  • Imaging of animal models of human diseases


    • PREVIOUS WORK EXPERIENCE
  • 1985-1988 Fogarty Visiting Fellow Department of Nuclear Medicine - Clinical Center and Neuroimaging Branch, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD,USA
  • 1989-1993 Clinical Associate at the Institute of Diagnostic Radiology and Nuclear Medicine- University of Naples "Federico II".
  • 1989-1996 Guest Researcher, Neuroimaging Branch, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD, USA
  • 1996 -2004 Director - Interdepartmental Center of Veterinary Radiology - Università degli Studi di Napoli "Federico II" Naples, Italy. Associate Researcher CNR Center for Nuclear Medicine
  • Supervisor - Bioimaging Section - Istituto di Biostrutture e Bioimmagini - Consiglio Nazionale delle Ricerche and Imaging 2001-2008


    • SELECTED PUBLICATIONS
    1. Rava R, Brunetti A, Spinosi G. [An enzymatic method for the determination of Hg++ content]. Boll Soc Ital Biol Sper 1981;57(16):1702-1705.
    2. Rava R, Spinosi G, Brunetti A. [Partial purification and characterization of a D-amino acid oxidase from the hepatopancreas of Octopus vulgaris]. Boll Soc Ital Biol Sper 1981;57(1):111-117.
    3. Yarchoan R, Berg G, Brouwers P, et al. Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine. Lancet 1987;1(8525):132-135.
    4. Brunetti A, Blasberg RG, Finn RD, Larson SM. Gallium-transferrin as a macromolecular tracer of vascular permeability. Int J Rad Appl Instrum B 1988;15(6):665-672.
    5. Kern KA, Brunetti A, Norton JA, et al. Metabolic imaging of human extremity musculoskeletal tumors by PET. J Nucl Med 1988;29(2):181-186. 6. Pizzo PA, Eddy J, Falloon J, et al. Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection. N Engl J Med 1988;319(14):889-896.
    7. Alger JR, Brunetti A. Phase-distortion-free in vivo surface coil proton spectroscopy. Magn Reson Med 1989;12(3):379-381.
    8. Alger JR, Brunetti A, Nagashima G, Hossmann KA. Assessment of postischemic cerebral energy metabolism in cat by 31P NMR: the cumulative effects of secondary hypoxia and ischemia. J Cereb Blood Flow Metab 1989;9(4):506-514.
    9. Alger JR, Brunetti A, Nagashima G, Hossmann KA. Evaluation of a newly discovered water suppression pulse sequence for high-field in vivo 1H surface coil NMR spectroscopy. Magn Reson Med 1989;11(1):73-84.
    10. Brooks RA, Brunetti A, Alger JR, Di Chiro G. On the origin of paramagnetic inhomogeneity effects in blood. Magn Reson Med 1989;12(2):241-248. 11. Brunetti A, Berg G, Di Chiro G, et al. Reversal of brain metabolic abnormalities following treatment of AIDS dementia complex with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine): a PET-FDG study. J Nucl Med 1989;30(5):581-590.
    12. Cuocolo A, Esposito S, Volpe M, Celentano L, Brunetti A, Salvatore M. Renal artery stenosis detection by combined Gates' technique and captopril test in hypertensive patients. J Nucl Med 1989;30(1):51-56.
    13. Otsuki H, Brunetti A, Owens ES, Finn RD, Blasberg RG. Comparison of iron-59, indium-111, and gallium-69 transferrin as a macromolecular tracer of vascular permeability and the transferrin receptor. J Nucl Med 1989;30(10):1676-1685.
    14. Salvatore M, Brunetti A. [Metabolic radiotherapy of hyperthyroidism]. Ann Ital Chir 1989;60(5):367-371.
    15. Bizzi A, Brooks RA, Brunetti A, et al. Role of iron and ferritin in MR imaging of the brain: a study in primates at different field strengths. Radiology 1990;177(1):59-65.
    16. Brunetti A, Nagashima G, Bizzi A, DesPres DJ, Alger JR. Cerebral blood flow in experimental ischemia assessed by 19F magnetic resonance spectroscopy in cats. Stroke 1990;21(10):1439-1444.
    17. De Souza B, Brunetti A, Fulham MJ, et al. Pituitary microadenomas: a PET study. Radiology 1990;177(1):39-44.
    18. Brunetti A, Soricelli A, Mansi L, Salvatore M. Functional brain imaging in AIDS-related dementia: a review. Antibiot Chemother 1991;43:227-234.
    19. Maurelli L, Cuocolo A, Lastoria S, et al. [131I-meta-iodobenzylguanidine scintigraphy in patients with a suspected pheochromocytoma. A comparison with CT and biohumoral parameters]. Radiol Med (Torino) 1991;82(6):839-843.
    20. Postiglione A, Nappi A, Brunetti A, et al. Relative protection from cerebral atherosclerosis of young patients with homozygous familial hypercholesterolemia. Atherosclerosis 1991;90(1):23-30.
    21. Alfano B, Brunetti A, Ciarmiello A, Salvatore M. Simultaneous display of multiple MR parameters with "quantitative magnetic color imaging". J Comput Assist Tomogr 1992;16(4):634-640.
    22. Brunetti A, Tedeschi E, Belfiore G, Salvatore M. [Neuroblastoma metastasis to the falx cerebri. A case report]. Radiol Med (Torino) 1992;83(4):467-470.
    23. Marano I, Brunetti A, Covello M, Belfiore G, Giovine S, Salvatore M. [Magnetic resonance in the diagnosis and follow-up of soft-tissue sarcomas]. Radiol Med (Torino) 1992;84(1-2):15-21.
    24. Maurea S, Maurelli L, Lastoria S, et al. [Familial pheochromocytoma in Sipple's syndrome. A comparison between scintigraphy with 131I-meta-iodobenzylguanidine, computed tomography and echography]. Radiol Med (Torino) 1992;83(4):486-490.
    25. Rotondo A, Grassi R, Catalano O, et al. [Lung interstitial disease in systemic sclerosis: semiologic characteristics with high-resolution computerized tomography and comparison with other methods]. Radiol Med (Torino) 1993;86(3):213-219.
    26. Brunetti A, Mangoni di SSML, Chirianni A, et al. [Scintigraphy with gallium-67 citrate in patients with AIDS: pathologic extrapulmonary uptake]. Radiol Med (Torino) 1994;87(5):683-687.
    27. Maurea S, Lastoria S, Klain M, et al. Diagnostic evaluation of thyroid involvement by histiocytosis X. J Nucl Med 1994;35(2):263-265.
    28. Alfano B, Brunetti A, Arpaia M, Ciarmiello A, Covelli EM, Salvatore M. Multiparametric display of spin-echo data from MR studies of brain. J Magn Reson Imaging 1995;5(2):217-225.
    29. Brunetti A, Soricelli A, Rotondo A, et al. Correlative morphologic and functional imaging for diagnosis, staging and follow up in AIDS: an overview. Q J Nucl Med 1995;39(3):201-211.
    30. Covelli EM, Stefano ML, Panico L, Elmo M, Frezza P, Brunetti A. [Primary neuroectodermal tumor with unusual spinal cord localization. A case report]. Radiol Med (Torino) 1995;89(3):362-364.
    31. De Rosa V, Mangoni di Stefano ML, Brunetti A, et al. Computed tomography and second-look surgery in ovarian cancer patients. Correlation, actual role and limitations of CT scan. Eur J Gynaecol Oncol 1995;16(2):123-129.
    32. Fatone G, Brunetti A, Lamagna F, Potena A. Dermoid sinus and spinal malformations in a Yorkshire terrier: diagnosis and follow-up. J Small Anim Pract 1995;36(4):178-180.
    33. Fulham MJ, Brunetti A, Aloj L, Raman R, Dwyer AJ, Di Chiro G. Decreased cerebral glucose metabolism in patients with brain tumors: an effect of corticosteroids. J Neurosurg 1995;83(4):657-664.
    34. Iaccarino V, Tedeschi E, Brunetti A, Soricelli A, Salvatore M. Congenital agenesis/aplasia of the internal carotid arteries: MRA and SPECT findings. J Comput Assist Tomogr 1995;19(6):987-990.
    35. Sijens PE, Knopp MV, Brunetti A, et al. 1H MR spectroscopy in patients with metastatic brain tumors: a multicenter study. Magn Reson Med 1995;33(6):818-826.
    36. Soricelli A, Postiglione A, Cuocolo A, et al. Effect of adenosine on cerebral blood flow as evaluated by single- photon emission computed tomography in normal subjects and in patients with occlusive carotid disease. A comparison with acetazolamide. Stroke 1995;26(9):1572-1576.
    37. Brunetti A, Alfano B, Soricelli A, et al. Functional characterization of brain tumors: an overview of the potential clinical value. Nucl Med Biol 1996;23(6):699-715.
    38. Postiglione A, Soricelli A, Covelli EM, et al. Premature aging in Werner's syndrome spares the central nervous system. Neurobiol Aging 1996;17(3):325-330.
    39. Roperto F, Brunetti A, Saviano L, Galati P. Morphologic alterations in the cilia of a cat. Vet Pathol 1996;33(4):460-462.
    40. Soricelli A, Mainenti PP, Leone D, et al. Evaluation of brain perfusion with high resolution single photon emission tomography in the diagnosis of brain death. Minerva Anestesiol 1996;62(6):209-212.
    41. Tedeschi E, Soricelli A, Brunetti A, et al. Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas. Eur J Nucl Med 1996;23(11):1478-1484.
    42. Alfano B, Brunetti A. Advances in brain imaging: a new ethical challenge. Ann Ist Super Sanita 1997;33(4):483-488.
    43. Alfano B, Brunetti A, Covelli EM, et al. Unsupervised, automated segmentation of the normal brain using a multispectral relaxometric magnetic resonance approach. Magn Reson Med 1997;37(1):84-93.
    44. Brunetti A, Tedeschi G, Di Costanzo A, et al. White matter lesion detection in multiple sclerosis: improved interobserver concordance with multispectral MRI display. J Neurol 1997;244(9):586-590.
    45. Fatone G, Lamagna F, Pasolini MP, Potena A, Brunetti A. Myelography in the dog with non-ionic contrast media at different iodine concentrations. J Small Anim Pract 1997;38(7):292-294.
    46. Alfano B, Quarantelli M, Brunetti A, et al. Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation. Magn Reson Med 1998;39(3):497-499.
    47. Brunetti A, Fulham MJ, Aloj L, et al. Decreased brain glucose utilization in patients with Cushing's disease. J Nucl Med 1998;39(5):786-790.
    48. Camera L, Brunetti A, Romano M, Larobina M, Marano I, Salvatore M. Morphological imaging of thymic disorders. Ann Med 1999;31 Suppl 2:57-62.
    49. Meomartino L, Fatone G, Brunetti A, Lamagna F, Potena A. Temporomandibular ankylosis in the cat: a review of seven cases. J Small Anim Pract 1999;40(1):7-10.
    50. Quarantelli M, Alfano B, Larobina M, et al. Frequency encoding for simultaneous display of multimodality images. J Nucl Med 1999;40(3):442-447.
    51. Tedeschi E, Marano I, Savarese F, et al. Neurological deficit following spinal anaesthesia: MRI and CT evidence of spinal cord gas embolism. Neuroradiology 1999;41(4):275-278.
    52. Alfano B, Brunetti A, Larobina M, et al. Automated segmentation and measurement of global white matter lesion volume in patients with multiple sclerosis. J Magn Reson Imaging 2000;12(6):799-807.
    53. Brunetti A, Postiglione A, Tedeschi E, et al. Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies. J Magn Reson Imaging 2000;11(3):260-266.
    54. Ciarmiello A, Brunetti A, Larobina M, et al. Assessment of scanner performance and normalization of estimated relaxation rate values. Magn Reson Imaging 2001;19(1):123-128.
    55. Meomartino L, Brunetti A. Images in medicine. Lymphosarcoma. Vet Radiol Ultrasound 2002;43(5):487.
    56. Meomartino L, Fatone G, Potena A, Brunetti A. Morphometric assessment of the canine hip joint using the dorsal acetabular rim view and the centre-edge angle. J Small Anim Pract 2002;43(1):2-6.
    57. Quarantelli M, Larobina M, Volpe U, et al. Stereotaxy-based regional brain volumetry applied to segmented MRI: validation and results in deficit and nondeficit schizophrenia. Neuroimage 2002;17(1):373-384.
    58. Russo M, Covelli EM, Meomartino L, Lamb CR, Brunetti A. Computed tomographic anatomy of the canine inner and middle ear. Vet Radiol Ultrasound 2002;43(1):22-26.
    59. Quarantelli M, Ciarmiello A, Morra VB, et al. Brain tissue volume changes in relapsing-remitting multiple sclerosis: correlation with lesion load. Neuroimage 2003;18(2):360-366.
    60. Covelli EM, Brunetti A, Di Lauro A, et al. Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease. Radiol Med (Torino) 2004;108(4):417-425.
    61. Quarantelli M, Berkouk K, Prinster A, et al. Integrated Software for the Analysis of Brain PET/SPECT Studies with Partial-Volume-Effect Correction. J Nucl Med 2004;45(2):192-201.
    62. Varrone A, Pellecchia MT, Amboni M, et al. Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease. Neurology 2004;63(11):2097-2103.
    63. Varrone A, Salvatore E, De Michele G, et al. Reduced striatal [123I]FP-CIT binding in SCA2 patients without parkinsonism. Ann Neurol 2004;55(3):426-430.
    64. Foti D, Chiefari E, Fedele M, et al. Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat Med 2005;11(7):765-773.
    65. Tamburrini S, Brunetti A, Brown M, Sirlin CB, Casola G. CT appearance of the normal appendix in adults. Eur Radiol 2005;15(10):2096-2103.
    66. Tedeschi G, Lavorgna L, Russo P, et al. Brain atrophy and lesion load in a large population of patients with multiple sclerosis. Neurology 2005;65(2):280-285.
    67. Lanzillo R, Prinster A, Scarano V, et al. Neuropsychological assessment, quantitative MRI and ApoE gene polymorphisms in a series of MS patients treated with IFN beta-1b. J Neurol Sci 2006.
    68. Prinster A, Quarantelli M, Orefice G, et al. Grey matter loss in relapsing-remitting multiple sclerosis: a voxel-based morphometry study. Neuroimage 2006;29(3):859-867.
    69. Tamburrini S, Brunetti A, Brown M, Sirlin C, Casola G. Acute appendicitis: diagnostic value of nonenhanced CT with selective use of contrast in routine clinical settings. Eur Radiol 2006.
    70. Minopoli G, Stante M, Napolitano F, et al. Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem 2007;282(2):831-835.
    71. Russo M, Meomartino L, Greco A, et al. Pregnancy detection in mice using ultrasound. Vet Rec 2007;160(13):446-447.
    Napoli 10-Nov-2008