PVEOut list of participants

PVEOut FP5 project- List of participants

Partner n°: 1 (Co-ordinator) Name: National Council for Research (CNR) / Centre for Nuclear Medicine Contact person: Dr. Bruno Alfano, Director Mailing address: Edificio 10 - Via Pansini, 5 80131 Napoli ITALY E-mail: quarante@unina.it Telephone Number: +39 - 081 7462226 FAX Number: +39 - 081 220 3187 Short Name: CNR-CMN
Partner n°: 2 Name: University of Kent at Canterbury - UK / Electronic Engineering Laboratories Contact person: Prof. Alan Colchester Mailing address: Kent CT2 7NT CT1 7NT Canterbury, UNITED KINGDOM E-mail: a.colchester@ukc.ac.uk Telephone Number: (44-1227) 827200 FAX Number: (44-1227) 827205 Short Name: UKC	Partner n°: 3 Name: Karolinska Institutet / Department of Clinical Neuroscience / Psychiatry Section / Karolinska Hospital Contact person: Prof. Lars Farde Mailing address:171 76 - Stockholm-SWEDEN E-mail: lars.farde@psyk.ks.se Telephone Number: (46-8)51772673 FAX Number: (46-8)51771753 Short Name: KI
Partner n°: 4 Name: MR Department at Hvidovre Hospital, Copenhagen Hospital Corporation (H:S), Copenhagen University Hospital Contact person: Prof. Olaf Paulson Mailing address: Kettegaard Alle 30 DK-2650 &emdash; Hvidovre &emdash; DENMARK E-mail: paulson@nru.dk Telephone Number: +45 3545 6710 FAX Number: +45 3545 6713 Short Name: H:S	Partner n°: 5 Name: INSERM U320 Contact person: Dr. J.C. Baron Mailing address: PO BOX BP 5229 Boulevard Henri Becquerel, Cyceron 14074 &emdash; Caen &emdash; FRANCE E-mail: baron@aries3.cyceron.fr Telephone Number: (33-2)31470219 FAX Number: (33-2)31470222 Short Name: Inserm
Partner n°: 6 Name: University Medical School of Debrecen / PET Centre Contact person: Prof. Tron Lajos Mailing address: PO BOX 52 Nagyerdei krt. 98 4012 &emdash; Debrecen &emdash; HUNGARY E-mail: tron@pet.dote.hu Telephone Number: 36 52 431 958 FAX Number: 36 52 431 958 Short Name: DPC	Partner n°: 7 Name: RASNA Imaging Systems Contact person: Dr. Eng. Fabio Buti Mailing address: Via Panciatichi, 26/3 50127 - Firenze - ITALY E-mail: lapo@rasnaimaging.com Telephone Number: +39 055 4369352 FAX Number: +39 055 413576 Short Name: RASNA

ROLE OF PARTICIPANTS:

Partner n°: 1
Name: National Council for Research (CNR) / Centre for Nuclear Medicine

Contact person: Dr. Bruno Alfano, Director

Mailing address: Edificio 10 - Via Pansini, 5 80131 Napoli ITALY

Electronic address: quarante@unina.it

Contractual links to other participants: None

Objectives: CNR-CNM will provide expertise in the field of brain MR segmentation, computer simulation of PET/SPECT image formation and multi-modality imaging presentation.

Workplan:

CNR-CNM will participate in WP1, employing a total of 10 person/months, including:

1 person/month for collaboration to the definition of the state of the art in the field of brain MRI segmentation
1 person/month for collaboration to the definition of the state of the art in the field of brain imaging studies co-registration
1 person/month for collaboration to the definition of the state of the art in the field of digital brain atlases
1 person/month for collaboration to the definition of Hardware and Software suitable platforms
6 person/month for definition of the state of the art in the field of PVE correction in Nuclear medicine and MRSI, and it will be responsible in this sense of the completion of Deliverable D4.

CNR-CNM will participate in WP2 for a total of 24 person/months, including:

2 person/months for collaboration to design of the segmentation modules
2 person/months for collaboration to the design of the co-registration modules
2 person/months for collaboration to the design of the digital brain atlas module for automated ROI definition
2 person/months for collaboration to design and writing of the Nuclear Medicine image-generation process simulator.
14 person/months for design and writing of the ROI-based PVE correction module, and it will be responsible in this sense of the completion of this module within Deliverable D5.
2 person/months for collaboration to the design of the PVE-corrected images generation module.

CNR-CNM will be the only participant in WP3 for a total of 14 person/months, and will be responsible for the design and the production of the anthropomorphic and geometric brain phantoms (Deliverable D6).
Stereolitography procedures will be subcontracted. Subcontractor is expected to provide active collaboration in the production of the phantoms, interacting with the design procedures, employing a total of 7 person/months.

CNR-CNM will participate in WP4 for a total of 22 person/months, including:

2 person/months for preliminary tests
18 person/months for implementation of modifications to phantoms and ROI-based PVE correction module , and it will be responsible in this sense of the completion of these products within Deliverable D7 and D8 (CNR-CNM will be coordinator of task 4B: phantom and software modification).
2 person/months for collaboration to final software and phantom validation.

CNR-CNM will not contribute significantly in terms of person/months to WP5, but it will provide cerebral blood flow SPECT (99mTc-HMPAO and ECD), neuroreceptor SPECT (123I-Iomazenil) and glucose metabolism PET (18F-FDG) studies from neuropsychiatry and neuro-oncology patients together with corresponding MR studies for analysis using PVEOut software.

Partner n°: 2
Name: University of Kent at Canterbury - UK / Electronic Engineering Laboratories

Contact person: Dr. Alan Colchester

Mailing address: Kent CT2 7NT / CT1 7NT - Canterbury, UNITED KINGDOM

Electronic address: a.colchester@ukc.ac.uk

Short Name: UKC

Contractual links to other participants: None

Objectives:

UKC will provide expertise in the field of brain MR segmentation and co-registration.
Furthermore UKC, an Institute with a leading international position in the field of Medical Image Computing, will ensure proper assessment of the hardware/software issues of the project.

Workplan:

UKC will participate in WP1, employing a total of 8 person/months, including:

4 person/month for the definition of the state of the art in the field of brain MRI segmentation, and it will be responsible in this sense of the completion of Deliverable D1
1 person/month for collaboration to the definition of the state of the art in the field of brain imaging studies co-registration
1 person/month for collaboration to the definition of the state of the art in the field of digital brain atlases
1 person/month for collaboration to the definition of Hardware and Software suitable platforms
1 person/month for definition of the state of the art in the field of PVE correction in Nuclear medicine and MRSI.

UKC will be responsible of WP2 and will employ in it a total of 23 person/months, including:

1 person/months for technical co-ordination tasks
9 person/months for design and writing of the segmentation modules, and it will be responsible in this sense of the completion of this module within Deliverable D5.
1 person/months for collaboration to the design of the co-registration modules
1 person/months for collaboration to the design of the digital brain atlas module for automated ROI definition
1 person/months for collaboration to the design writing of the Nuclear Medicine image-generation process simulator,
1 person/months for collaboration to the design of the ROI-based PVE correction module.
9 person/months for the design and writing of the PVE-corrected images generation module, and it will be responsible in this sense of the completion of this module within Deliverable D5.

UKC will participate in WP4 for a total of 20 person/months, including:

2 person/months for preliminary tests
12 person/months for implementation of modifications to segmentation and PVE-corrected images generation module , and it will be responsible in this sense of the completion of these products within Deliverable D7.
6 person/months for collaboration to final software and phantom validation.

Partner n°: 3
Name: Karolinska Institutet / Department of Clinical Neuroscience / Psychiatry Section / Karolinska Hospital

Contact person: Dr. Lars Farde

Mailing address: 171 76 -Stockholm-SWEDEN

E-mail: lars.farde@psyk.ks.se

Short Name: KI

Contractual links to other participants: None

Objectives: KI will provide expertise in the field of psychiatric application of functional imaging, particularly neuroreceptor NM studies, as well as applications of digital brain atlases and partial volume correction techniques to Nuclear Medicine brain studies.

Workplan:

KI will participate in WP1, employing a total of 10 person/months, including:

1 person/month for collaboration to the definition of the state of the art in the field of brain MRI segmentation
1 person/month for collaboration to the definition of the state of the art in the field of brain imaging studies co-registration
8 person/month for the definition of the state of the art in the field of digital brain atlases, and it will be responsible in this sense of the completion of Deliverable D3
1 person/month for collaboration to the definition of Hardware and Software suitable platforms
1 person/month for definition of the state of the art in the field of PVE correction in Nuclear medicine and MRSI.

KI will be responsible of WP2 and will employ in it a total of 24 person/months, including:

7 person/months for the design and writing of the digital brain atlas module for automated ROI definition
2 person/months for collaboration to the design writing of the Nuclear Medicine image-generation process simulator,
2 person/months for collaboration to the design of the ROI-based PVE correction module.
2 person/months for collaboration to the design and writing of the PVE-corrected images generation module

KI will participate in WP4 for a total of 11 person/months, including:

2 person/months for preliminary tests
9 person/months for implementation of modifications to the digital brain atlas module, and it will be responsible in this sense of the completion of these products within Deliverable D7.

KI will be responsible for WP5 completion and will provide Neuroreceptor PET and MR Spectroscopy studies of psychiatric patients, together with matched MRI for application of PVE correction techniques. It will participate in WP5 for a total of 12 person/months including:

2 person/months for scientific co-ordination tasks
2 person/months for application of the software to on-site available studies
1 person/month for collaboration to application of the software studies from Centres who may have joined later the project providing Nuclear medicine and MRSI studies, together with matched MRI, for testing PVEOut
7 person/months for definition of state of the art protocols for Nuclear Medicine and Spectroscopy image analysis, including PVE correction, in psychiatry. In this sense KI will be responsible of the the part relating to research and clinical diagnostic imaging in psychiatry of deliverables D9 and D10.

Partner n°: 4
Name: MR Department at Hvidovre Hospital, Copenhagen Hospital Corporation (H:S), Copenhagen University Hospital

Contact person: Dr. Olaf Paulson

Mailing address: Kettegaard Alle 30

DK-2650 - Hvidovre - DENMARK

E-mail: paulson@nru.dk

Short Name: H:S

Contractual links to other participants: None

Objectives: H:S will provide expertise in the field of MR spectroscopy, clinical research activities in multi-modality imaging in brain cerebrovascular disease, dementia, and multiple sclerosis.

Workplan:

H:S will participate in WP1, employing a total of 14 person/months, including:

2 person/month for collaboration to the definition of the state of the art in the field of brain MRI segmentation
6 person/month for collaboration to the definition of the state of the art in the field of brain imaging studies co-registration
2 person/month for collaboration to the definition of the state of the art in the field of digital brain atlases
2 person/month for collaboration to the definition of Hardware and Software suitable platforms
2 person/month for definition of the state of the art in the field of PVE correction in Nuclear medicine and MRSI.

H:S will participate in WP2 and will employ in it a total of 16 person/months, including:

16 person/months for design and writing of the co-registration modules, and will be responsible in this sense of the completion of this module within Deliverable D5.

H:S will participate in WP4 for a total of 12 person/months, including:

2 person/months for testing of the software
10 person/months for implementation of modifications to the co-registration module, and it will be responsible in this sense of the completion of these products within Deliverable D7.

H:S will provide MR Spectroscopy studies of neurologic patients, together with matched MRI for application of PVE correction techniques. It will participate in WP5 for a total of 18 person/months including:

3 person/months for application of the software to on-site available studies
3 person/month for collaboration to application of the software studies from Centres who may have joined later the project providing Nuclear medicine and MRSI studies, together with matched MRI, for testing PVEOut
12 person/months for definition of state of the art protocols for Nuclear Medicine and Spectroscopy image analysis, including PVE correction, in Neurology. In this sense H:S will be responsible of the the part relating to research and clinical diagnostic imaging in Neurology of deliverables D9 and D10.

Partner n°: 5
Name: INSERM / CYCERON, Caen

Contact person: Prof. J.C. Baron

Mailing address: PO BOX BP 5229

Boulevard Henri Becquerel, Cyceron

14074 - Caen - FRANCE

E-mail: baron@aries3.cyceron.fr

Short Name: Inserm

Contractual links to other participants: None

Objectives: Inserm will not participate in the preliminary software designand writing tasks, but will be responsible of the validation workpackage, to ensure independency of the evaluation process.
It will also provide opportunities for application of the PVEOut software to neurodegenerative disorders (its main area of diagnostic neuroimaging research ), where impact of PVE-correction is expected to be the greatest.

Workplan:
Inserm will participate in WP1, employing a total of 7 person/months, including:

1 person/month for collaboration to the definition of the state of the art in the field of brain MRI segmentation
1 person/month for collaboration to the definition of the state of the art in the field of brain imaging studies co-registration
2 person/month for collaboration to the definition of the state of the art in the field of digital brain atlases
3 person/month for collaboration to definition of the state of the art in the field of PVE correction in Nuclear medicine and MRSI.

Inserm will be responsible of WP4 and will participate in it for a total of 22 person/months, including:

2 person/months for co-ordination of scientific aspects of the validation process
4 person/months for preliminary tests
2 person/months for collaboration to modifications to segmentation module
2 person/months for collaboration to modifications to co-registration module
2 person/months for collaboration to modifications of the digital brain atlas module for automated ROI definition
2 person/months for collaboration to modifications of the Nuclear Medicine image-generation process simulator.
2 person/months for collaboration to modifications to phantoms
2 person/months for collaboration to modification of the ROI-based PVE correction module.
2 person/months for collaboration to modification of the PVE-corrected images generation module.
2 person/months for collaboration to final software and phantom validation.

Inserm will provide Glucose metabolism (18F-FDG) and Cerebral blood flow (15O) PET studies from research protocols on the pathophysiology of neurodegenerative diseases (Alzheimer, Parkinson), aging, stroke and functional recovery, together with corresponding MR studies for analysis using PVEOut software within WP5.
Inserm will participate to WP5 for a total of 16 person/months, including:

3 person/months for application of the software to on-site available studies
1 person/month for collaboration to application of the software studies from Centres who may have joined later the project providing Nuclear medicine and MRSI studies, together with matched MRI, for testing PVEOut
12 person/months for definition of state of the art protocols for Nuclear Medicine and Spectroscopy image analysis, including PVE correction, in Neurodegenerative diseases.

Partner n°: 6
Name: University Medical School of Debrecen / PET Centre

Contact person: Dr. Tron Lajos

Mailing address: PO BOX 52

Nagyerdei krt. 98

4012 - Debrecen - HUNGARY

E-mail: tron@pet.dote.hu

Contractual links to other participants: None

Objectives: DPC will provide expertise in the field of clinical PET in neurology and psychiatry, and will be mainly in charge of the computer simulation of Nuclear Medicine image generation process, necessary to generate algorithms for PVE-correction and for preliminary tests (virtual PET phantoms).

Workplan:

DPC will participate in WP1, employing a total of 6 person/months, including:

1 person/month for collaboration to the definition of the state of the art in the field of brain MRI segmentation
1 person/month for collaboration to the definition of the state of the art in the field of brain imaging studies co-registration
1 person/month for collaboration to the definition of the state of the art in the field of digital brain atlases
1 person/month for collaboration to the definition of Hardware and Software suitable platforms
2 person/month for collaboration to definition of the state of the art in the field of PVE correction in Nuclear medicine and MRSI.

DPC will participate in WP2 for a total of 24 person/months, including:

2 person/months for collaboration to design of the segmentation modules
2 person/months for collaboration to the design of the co-registration modules
2 person/months for collaboration to the design of the digital brain atlas module for automated ROI definition
14 person/months for design and writing of the Nuclear Medicine image-generation process simulator, and it will be responsible in this sense of the completion of this module within Deliverable D5.
2 person/months for collaboration to design of the ROI-based PVE correction module.
2 person/months for collaboration to the design of the PVE-corrected images generation module.

DPC will participate in WP4 for a total of 28 person/months, including:

2 person/months for preliminary tests
20 person/months for implementation of modifications to phantoms and ROI-based PVE correction module , and it will be responsible in this sense of the completion of these products within Deliverable D7 and D8.
2 person/months for collaboration to modification of the ROI-based PVE correction module.
2 person/months for collaboration to modification of the PVE-corrected images generation module.
2 person/months for collaboration to final software and phantom validation.

DPC will provide cerebral blood flow SPECT (99mTc-HMPAO and ECD), glucose metabolism (18F-FDG) and Cerebral blood flow (15O) studies from neuropsychiatry and neuro-oncology patients together with corresponding MR studies for analysis using PVEOut software.
DPC will participate to WP5 for a total of 12 person/months, including:

3 person/months for application of the software to on-site available studies
1 person/month for collaboration to application of the software studies from Centres who may have joined later the project providing Nuclear medicine and MRSI studies, together with matched MRI, for testing PVEOut
13 person/months for definition of state of the art protocols for Nuclear Medicine and Spectroscopy image analysis, including PVE correction, in Neurology. In this sense DPC will be responsible of the the part relating to research and clinical diagnostic imaging in Nuerology of deliverables D9 and D10.

Partner n°: 7
Name: RASNA Imaging Systems

Contact person: Auro Pampaloni

Mailing address: Via Panciatichi, 26/3

50127 - Firenze - ITALY

E-mail: lapo@rasnaimaging.com

Short Name: RASNA

Contractual links to other participants: None

Objectives: RASNA will provide expertise in the field of the diagnostic images transmission and management protocols, in particular DICOM, and in the industrial exploitation of the medical software.
RASNA will also collaborate to an appropriate assessment of the hardware/software issue of the project

Workplan:

RASNA will participate in WP1, employing a total of 5 person/months, including:

5 person/month for collaboration to the definition of Hardware and Software suitable platforms and it will be responsible in this sense of the achievement of Milestone M1

RASNA will participate in WP2 for a total of 20 person/months, including:

1 person/months for collaboration to design of the segmentation modules
1 person/months for collaboration to the design of the co-registration modules
1 person/months for collaboration to the design of the digital brain atlas module for automated ROI definition
1 person/months for design and writing of the Nuclear Medicine image-generation process simulator
1 person/months for collaboration to design of the ROI-based PVE correction module.
1 person/months for collaboration to the design of the PVE-corrected images generation module.
12 person/months for design and writing of the main program (and corresponding manuals) which will include all the above mentioned modules, in particular reguarding a suitable Graphical-User Interface, and it will be responsible of the Task 2B (Software writing) and of completion of the main program within Deliverable D5.
2 person/months to collaborate to installation and set-up of the software prototypes at participating Centres.

RASNA will participate in WP4 for a total of 11 person/months, including:

1 person/months for collaboration to preliminary tests
8 person/months for modification of the main program (and corresponding manuals), and it will be responsible of the completion of the main program within Deliverable D7.
1 person/months for collaboration to final software and phantom validation.
1 person/months for collaboration to final software installation and set-up at participating Centres.