The smoothing process inherent to low-resolution functional imaging techniques
(e.g. PET and SPECT), does not allow to discriminate between thinner (i.e
atrophic) and hypometabolic (i.e. with normal thickness and reduced tracer
uptake) structures.
In the movie below two structures are simulated:
the vertical strip on the left has alternating thickness but constant
mean value
the vertical strip on the right has alternating gray intensity but
constant thickness
Reduced thickness
--------------->
--------------->
--------------->
Low intensity
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<---------------
<---------------
The smoothing of these two different images, introducing
PVE, results practically in the same image.